The Dopamine Hypothesis of Schizophrenia: An Historical Perspective

von freakoutcrazy

A chapter from the soon-to-be-released “Targets and Emerging Therapies for Schizophrenia” explores the history of the dopamine hypothesis, finding thatalthough blocking of D2DR ameliorates psychosis, this does not necessarily mean that the dopamine system is abnormal in schizophrenia.” The authors go on to say; “Vigorous search for abnormalities in the dopamine system in schizophrenia so far has yielded inconclusive results … any simple, exclusive pathology of the dopamine system in schizophrenia was and is doubtful.”