CAFÉ Study: Real Science or Marketing Exercise?
Any discussion of CAFÉ must begin with a review of CATIE (Clinical Antipsychotic Trials of Intervention Effectiveness).
CATIE was a randomized trial funded by the US government (NIMH). It was written up in three phases: Phase 1 (Lieberman J et al, 2005); Phase 2 Part a (McEvoy JP et al, 2006) and Phase 2 Part b (Stroup TS et al, 2006); and CATIE Phase 3 (Stroup TS et al, 2009). CATIE’s purpose was to compare old neuroleptics with new neuroleptics. There was no placebo. This reflected the belief/assumption that the efficacy of neuroleptics generally had already been established. The researchers compared the old drug perphenazine with the second generation neuroleptics olanzapine, quetiapine, risperidone, and ziprasidone. The conclusion: